INJE PharmacoGenomics Research Center

· Bae SK, Kang MJ, Yeo CW, Kim MJ, Shon JH, Liu KH, Shin JG.

Simultaneous determination of udenafil and its active metabolite, DA-8164, in human plasma and urine using ultra-performance liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study. (BMRC)

Biomed Chromatogr. 2008 Sep;22(9):939-46 [LINK]

2008-International

· Lee SS, Cha EY, Jung HJ, Shon JH, Kim EY, Yeo CW, Shin JG.

Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity. (BMRC, PRCDM)

Hepatology. 2008 Aug;48(2):635-45 [LINK]

2008-International

· Seo KA, Kim H, Ku HY, Ahn HJ, Park SJ, Bae SK, Shin JG, Liu KH.

The monoterpenoids citral and geraniol are moderate inhibitors of CYP2B6 hydroxylase activity. ()

Chem Biol Interact. 2008 Jun 20. [LINK]

2008-International

· Kim KB, Seo KA, Yoon YJ, Bae MA, Cheon HG, Shin JG, Liu KH.

In vitro metabolism of a novel PPARgamma agonist, KR-62980, and its stereoisomer, KR-63198, in human liver microsomes and by recombinant cytochrome P450s. (PRCDM)

Xenobiotica. 2008 May 3:1-12. [LINK]

· Bae SK, Cao S, Seo KA, Kim H, Kim MJ, Shon JH, Liu KH, Zhou HH, Shin JG.

Cytochrome P450 2B6 Catalyzes the Formation of Pharmacologically Active Sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) Metabolites in Human Liver Microsomes. ()

Drug Metab Dispos. 2008 Aug;36(8):1679-88. [LINK]

2008-International

· Deng JW, Song IS, Shin HJ, Yeo CW, Cho DY, Shon JH, Shin JG.

The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. ()

Pharmacogenet Genomics. 2008 May;18(5):424-33. [LINK ]

2008-International

· Pan W, Ryu JY, Shon JH, Song IS, Liu KH, Sunwoo YE, Kang W, Shin JG.

Dietary salt does not influence the disposition of verapamil enantiomers in relation to efflux transporter ABCB1 genetic polymorphism in healthy Korean subjects. ()

Xenobiotica. 2008 Apr;38(4):422-34. [LINK]

2008-International

· Kim H, Kim KB, Ku HY, Park SJ, Choi H, Moon JK, Park BS, Kim JH, Su Yea S, Lee CH, Lee HS, Shin JG, Liu KH.

Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China. ()

Drug Metab Dispos. 2008 Jun;36(6):1010-5. [LINK]

2008-International

· Ku HY, Ahn HJ, Seo KA, Kim H, Oh M, Bae SK, Shin JG, Shon JH, Liu KH.

The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. ()

Drug Metab Dispos. 2008 Jun;36(6):986-90. [LINK]

2008-International

· Bae SK, Seo KA, Jung EJ, Kim HS, Yeo CW, Shon JH, Park KM, Liu KH, Shin JG.

Determination of acetylsalicylic acid and its major metabolite, salicylic acid, in human plasma using liquid chromatography-tandem mass spectrometry: application to pharmacokinetic study of Astrix in Korean healthy volunteers. ()

Biomed Chromatogr. 2008 Jun;22(6):590-5. [LINK]

2008-International

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